Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors

Abstract Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB (G3 MB) subtype accounts for about 25% of MB and is associated with the worst outcomes. Herein, we report that more than half of G3 MB tumors express melanoma antigens (MAGEs), which are potential prognostic and t...

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Prif Awduron:	Rebecca R. J. Collins, Rebecca R. Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K. Lee, Samuel T. Peters, Jon P. Connelly, Shondra M. Pruett-Miller, Martine F. Roussel, Dinesh Rakheja, Heather S. Tillman, Patrick Ryan Potts, Klementina Fon Tacer
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-07-01
Cyfres:	Acta Neuropathologica Communications
Pynciau:	Medulloblastoma Tumor antigens MAGE Pediatric cancer Cancer-testis antigens
Mynediad Ar-lein:	https://doi.org/10.1186/s40478-025-02055-3
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