Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome

Summary: Stress-elevated glucocorticoids cause circadian disturbances and gut-brain axis (GBA) disorders, including irritable bowel syndrome (IBS). We hypothesized that the glucocorticoid receptor (GR/NR3C1) might cause chromatin circadian misalignment in the colon epithelium. We observed significan...

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Hlavní autoři:	Gen Zheng, Suya Pang, Junbao Wang, Fangyu Wang, Qi Wang, Lili Yang, Mengdie Ji, Dejian Xie, Shengtao Zhu, Yang Chen, Yan Zhou, Gerald A. Higgins, John W. Wiley, Xiaohua Hou, Rong Lin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-07-01
Edice:	iScience
Témata:	Molecular biology Neuroscience Transcriptomics
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2589004223012142
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