Enhancing CAR-T cell activity prediction via fine-tuning protein language models with generated CAR sequences
Abstract Background Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable success in treating hematological malignancies. However, several challenges remain, including limited efficacy against solid tumors, T cell exhaustion, and lack of T cell persistence, which have restricted its cl...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BMC
2026-02-01
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| Seri Bilgileri: | BMC Bioinformatics |
| Konular: | |
| Online Erişim: | https://doi.org/10.1186/s12859-026-06401-7 |
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