Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

Abstract Background Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug delivery and efficacy for a successful cancer treatment. However, surface functionalization involves complex procedures th...

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Autori principali:	José L. Blaya-Cánovas, Carmen Griñán-Lisón, Isabel Blancas, Juan A. Marchal, César Ramírez-Tortosa, Araceli López-Tejada, Karim Benabdellah, Marina Cortijo-Gutiérrez, M. Victoria Cano-Cortés, Pablo Graván, Saúl A. Navarro-Marchal, Jaime Gómez-Morales, Violeta Delgado-Almenta, Jesús Calahorra, María Agudo-Lera, Amaia Sagarzazu, Carlos J. Rodríguez-González, Tania Gallart-Aragón, Christina Eich, Rosario M. Sánchez-Martín, Sergio Granados-Principal
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-05-01
Serie:	Molecular Cancer
Soggetti:	Biomimetic nanoparticles Immune evasion PD1 PDL1 T-cell exhaustion Immune checkpoint
Accesso online:	https://doi.org/10.1186/s12943-024-01997-x
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