Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

Abstract Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients. This study was conducted to quantify and compare the solubility of lamotrigine in age-specific biorelevant media that simulated the fas...

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Autores principales:	Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco, Xavier Declèves
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-09-01
Colección:	BMC Biotechnology
Materias:	Lamotrigine Pediatric Solubility Dosage form performance Biopharmaceutics Biorelevant
Acceso en línea:	https://doi.org/10.1186/s12896-023-00809-2
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