Non-synonymous to synonymous substitutions suggest that orthologs tend to keep their functions, while paralogs are a source of functional novelty

Orthologs separate after lineages split from each other and paralogs after gene duplications. Thus, orthologs are expected to remain more functionally coherent across lineages, while paralogs have been proposed as a source of new functions. Because protein functional divergence follows from non-syno...

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Detalhes bibliográficos

Principais autores:	Juan M. Escorcia-Rodríguez, Mario Esposito, Julio A. Freyre-González, Gabriel Moreno-Hagelsieb
Formato:	Artigo
Idioma:	Inglês
Publicado em:	PeerJ Inc. 2022-08-01
Colecção:	PeerJ
Assuntos:	Orthologs Paralogs Nonsynonymous to synonymous substitutions dN/dS Functional divergence Positive selection
Acesso em linha:	https://peerj.com/articles/13843.pdf
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