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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

<p>Abstract</p> <p>Background</p> <p>TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 expression and formation of C-terminal TDP-43 fragmentation and accumulation in the cytoplasm. Recent studies have shown that TDP-43 can accumulate in RNA stress granules (SGs) in response to cell...

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Principais autores: Masters Colin L, Li Qiao-Xin, Caragounis Aphrodite, Liddell Jeffrey R, Price Katherine A, Ng Dominic CH, Vella Laura J, Parker Sarah J, Meyerowitz Jodi, Nonaka Takashi, Hasegawa Masato, Bogoyevitch Marie A, Kanninen Katja M, Crouch Peter J, White Anthony R
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2011-08-01
Series:Molecular Neurodegeneration
Assuntos:
TDP-43
stress granules
JNK
kinases
oxidative stress
paraquat
hnRNP
Acceso en liña:http://www.molecularneurodegeneration.com/content/6/1/57
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