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Inhibition of ABI2 ubiquitination-dependent degradation suppresses TNBC cell growth via down-regulating PI3K/Akt signaling pathway

Abstract Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanisms. Recent evidence shows that the ubiquitin-protease system is closely related to TNBC. In this study, we obtain a key ubiquitination regulatory substrate-ABI2 protein...

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Principais autores: Linlin Lv, Shujing Li, Jie Kang, Yulin Li, Nannan Zhao, Dongman Ye, Fengying Qin, Jing Sun, Tao Yu, Huijian Wu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-06-01
coleção:Cancer Cell International
Assuntos:
TNBC
ABI2
CBLC
PI3K/Akt
Colistimethate sodium
Acesso em linha:https://doi.org/10.1186/s12935-024-03407-0
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