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Efficacy and safety of DPP-1 inhibitors in bronchiectasis: a GRADE-assessed meta-analysis of randomized controlled trials

Abstract Background Bronchiectasis is a chronic inflammatory airway disease characterized by frequent exacerbations and neutrophilic inflammation. Dipeptidyl peptidase-1 (DPP-1) inhibitors block neutrophil serine protease activation and represent a promising therapeutic approach. This meta-analysis...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Ahmed Emara, Ameer Awashra, Mohamed Ellebedy, Omar F. Abbas, Ahmed Diaa, Mohamed S. Elgendy, Mohamed Emara, Abdalhakim Shubietah, Abdul Muhsen Z. Abdeen, Fadi Safi
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-11-01
Rangatū:Respiratory Research
Ngā marau:
Bronchiectasis
DPP-1 inhibitor
Brensocatib
Exacerbation
Neutrophil elastase
Meta-analysis
Urunga tuihono:https://doi.org/10.1186/s12931-025-03407-2
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