A Cisplatin-Based Prodrug Inhibits Nucleotide Excision Repair Independently of Chromatin Accessibility to Overcome Resistance

Cisplatin [<i>cis</i>-diamminedichloroplatinum(II)] is a widely used chemotherapeutic agent that induces cytotoxicity primarily through DNA damage; however, drug resistance severely limits its efficacy. Cisplatin resistance is complex and multifactorial, involving DNA repair via nucleotide excision...

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Autori principali:	Ya’ara Negev-Korem, Hadar Golan-Berman, Elisheva Heilbrun, Subhendu Karmakar, Yoram Soroka, Marina Frušić-Zlotkin, Ofer Chen, Hiba Hassanain, Esther Stern, Ori Wald, Dan Gibson, Ron Kohen, Sheera Adar
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-04-01
Serie:	Biomolecules
Soggetti:	cisplatin DNA damage DNA repair nucleotide excision repair chromatin KDAC
Accesso online:	https://www.mdpi.com/2218-273X/16/4/542
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