Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach

Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised a series of digoxin derivatives (γ-Benzyliden...

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Autors principals:	Marco T. C. Pessôa, Silmara L. G. Alves, Alex G. Taranto, José A. F. P. Villar, Gustavo Blanco, Leandro A. Barbosa
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2018-01-01
Col·lecció:	Journal of Enzyme Inhibition and Medicinal Chemistry
Matèries:	Cardiotonic steroids digoxin Na,K-ATPase isoforms molecular docking
Accés en línia:	http://dx.doi.org/10.1080/14756366.2017.1380637
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