The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma

It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not normal cells. This concept was translat...

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Bibliografische Detailangaben

Hauptverfasser:	Niramol Savaraj, Chunjing Wu, Marcus Tien Kuo, Min You, Medhi Wangpaichitr, Carlos Robles, Seth Spector, Lynn Feun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	AboutScience Srl 2007-01-01
Schriftenreihe:	Drug Target Insights
Online-Zugang:	https://doi.org/10.1177/117739280700200016
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