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Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells

Ovarian cancer accounts for 3% of the total cancers in women, yet it is the fifth leading cause of cancer deaths among women. The BRCA1/2 germline and somatic mutations confer a deficiency of the homologous recombination (HR) repair pathway. Inhibitors of poly (ADP-ribose) polymerase (PARP), another...

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Principais autores: Olivia El Naggar, Brenna Doyle, Kelsey Mariner, Susan K. Gilmour
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-05-01
Serier:Medical Sciences
Fag:
polyamines
difluoromethylornithine
rucaparib
PARP inhibition
ovarian cancer
Online adgang:https://www.mdpi.com/2076-3271/10/2/28
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