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Integrating endothelium-derived hyperpolarization, nitric oxide, and prostacyclin pathways: the multimodal potential of human tissue kallikrein-1

Endothelial cells regulate vascular tone by releasing nitric oxide (NO) and prostacyclin (PGI2), as well as by initiating hyperpolarization of vascular smooth muscle cells through K+ channels and myoendothelial coupling. This review highlights the therapeutic potential of targeting endothelium-depen...

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Bibliografiske detaljer
Principais autores: Paolo Madeddu, Styliani Goulopoulou, David Wambeke
Format: Artigo
Sprog:Inglês
Udgivet: Bioscientifica 2025-11-01
Serier:Vascular Biology
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Online adgang:https://vb.bioscientifica.com/view/journals/vb/7/1/VB-25-0006.xml
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