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Hyperthermia improves gemcitabine sensitivity of pancreatic cancer cells by suppressing the EFNA4/β-catenin axis and activating dCK

Background: Previously, our investigations have underscored the potential of hyperthermia to improve the therapeutic efficacy of gemcitabine (GEM) in pancreatic cancer (PC). Nonetheless, the precise underlying mechanisms remain elusive. Methods: We engineered two GEM-resistant PC cell lines (BxPC-3/...

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Huvudupphov: Qiaoxian He, Yangyang Zheng, Lei Lu, Hongzhang Shen, Weigang Gu, Jianfeng Yang, Xiaofeng Zhang, Hangbin Jin
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2024-04-01
Serie:Heliyon
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Länkar:http://www.sciencedirect.com/science/article/pii/S2405844024045195
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