Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection

Abstract Topoisomerase II alpha and beta (TOP2A and TOP2B) isoenzymes perform essential and non-redundant cellular functions. Anthracyclines induce their potent anti-cancer effects primarily via TOP2A, but at the same time they induce a dose limiting cardiotoxicity through TOP2B. Here we describe th...

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Detalhes bibliográficos

Principais autores:	Jan Kubeš, Galina Karabanovich, Anh T. Q. Cong, Iuliia Melnikova, Olga Lenčová, Petra Kollárová, Hana Bavlovič Piskáčková, Veronika Keresteš, Lenka Applová, Lise C. M. Arrouye, Julia R. Alvey, Jasmina Paluncic, Taylor L. Witter, Anna Jirkovská, Jiří Kuneš, Petra Štěrbová-Kovaříková, Caroline A. Austin, Martin Štěrba, Tomáš Šimůnek, Jaroslav Roh, Matthew J. Schellenberg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-05-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-60167-9
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