The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Vilazodone (VLZ) is a drug for the treatment of major depressive disorders that targets the serotonin transporter (SERT). Here, the authors combine pharmacology measurements and cryo-EM structural analysis to characterize VLZ binding to SERT and observe that VLZ exhibits non-competitive inhibition o...

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Autors principals:	Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E. Kalenderoglou, Amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2021-08-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-021-25363-3
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