Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

Abstract DNA polymerase III sliding clamp (DnaN) was recently validated as a new anti-tuberculosis target employing griselimycins. Three (2 S,4 R)−4-methylproline moieties of methylgriselimycin play significant roles in target binding and metabolic stability. Here, we identify the mycoplanecin biosy...

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Principais autores:	Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D. Bader, Peer Lukat, Markus Neuber, F. P. Jake Haeckl, Wulf Blankenfeldt, Olga V. Kalinina, Rolf Müller
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-01-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-024-44953-5
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