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Targeting the delivery of systemically administered haematopoietic stem/progenitor cells to the inflamed colon using hydrogen peroxide and platelet microparticle pre-treatment strategies

Haematopoietic stem and progenitor cell (HSC) therapy may be promising for the treatment of inflammatory bowel disorders (IBDs). However, clinical success remains poor, partly explained by limited HSC recruitment following systemic delivery. The mechanisms governing HSC adhesion within inflamed colo...

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Principais autores: Adrian Yemm, David Adams, Neena Kalia
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-11-01
Serier:Stem Cell Research
Fag:
Haematopoietic stem cells
Colon
Colitis
Ischaemia–reperfusion injury
Platelet microparticles
Hydrogen peroxide
Online adgang:http://www.sciencedirect.com/science/article/pii/S187350611500135X
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