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TEAD Inhibitors Sensitize KRAS<sup>G12C</sup> Inhibitors via Dual Cell Cycle Arrest in KRAS<sup>G12C</sup>-Mutant NSCLC

KRAS<sup>G12C</sup> is one of the most common mutations detected in non-small cell lung cancer (NSCLC) patients, and it is a marker of poor prognosis. The first FDA-approved KRAS<sup>G12C</sup> inhibitors, sotorasib and adagrasib, have been an enormous breakthrough for patients with KRAS<sup>G12C</s...

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Principais autores: Salvina Laura Tammaccaro, Philippe Prigent, Jean-Christophe Le Bail, Odette Dos-Santos, Laurent Dassencourt, Myriam Eskandar, Armelle Buzy, Olivier Venier, Jean-Claude Guillemot, Yaligara Veeranagouda, Michel Didier, Emmanuel Spanakis, Tokuwa Kanno, Matteo Cesaroni, Stephane Mathieu, Luc Canard, Alhassan Casse, Fanny Windenberger, Loreley Calvet, Laurence Noblet, Sukhvinder Sidhu, Laurent Debussche, Jurgen Moll, Iris Valtingojer
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-04-01
coleção:Pharmaceuticals
Assuntos:
YAP1-TEAD
resistance
KRAS<sup>G12C</sup>
NSCLC
cell cycle arrest
Acesso em linha:https://www.mdpi.com/1424-8247/16/4/553
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