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Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease

Abstract Background The presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the identification of coronary stenosis. Testing by coronary computed tomography angiography (CCTA) enables the identification of high-risk plaques (HRP). Ref...

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Principais autores: Peter Loof Møller, Palle Duun Rohde, Jonathan Nørtoft Dahl, Laust Dupont Rasmussen, Louise Nissen, Samuel Emil Schmidt, Victoria McGilligan, Daniel F. Gudbjartsson, Kari Stefansson, Hilma Holm, Jacob Fog Bentzon, Morten Bøttcher, Simon Winther, Mette Nyegaard
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-03-01
coleção:Genome Medicine
Assuntos:
High-risk coronary plaque
Coronary artery disease
Prediction
Genetics
Olink proteomics
Acesso em linha:https://doi.org/10.1186/s13073-024-01313-8
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