LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling

Abstract Background High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and chemoresistance. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. This study investigates the role of the cytoplasmic lncRNA LINC02888 in HGSOC. Methods...

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Үндсэн зохиолчид:	BingJie Rui, YanFeng Yang, DanBo Geng, ZiTeng Kuang, TianLi Mu, YuXi Liu, Bo Ren, RunZe He, XiaoWei Zhang, YuCi Zhang, Min Wang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-06-01
Цуврал:	Journal of Translational Medicine
Нөхцлүүд:	LINC02888 PPIB LAPTM5 RIG-I-like receptor pathway Immune evasion
Онлайн хандалт:	https://doi.org/10.1186/s12967-025-06650-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!