Distinct pulmonary pathophysiological mechanisms in COPD, bronchiectasis, and primary immunodeficiency: a multi-omics investigation of disease heterogeneity via sputum and blood profiling

Abstract Background Bronchiectasis (BE), Chronic Obstructive Pulmonary Disease (COPD) and Primary Immunodeficiency (PID) are distinct respiratory conditions that share features such as chronic inflammation, airway obstruction, and recurrent infections. Despite distinct underlying causes, disease man...

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Auteurs principaux:	Stefanie Graeter, Nathalia Gonzalez-Jaramillo, Mattheus H. E. Wildschut, Luigi Capriotti, Moritz Saxenhofer, Jose Ramon Robador, Katherine Monaghan, Naomi Woodman, Judith Field, Nick Wilson, Megan Rees, Maria Hauswald, Carlos P. Roca, Annette Feussner, Ilka Schulze, Alastair Stewart, Alexander Schaub, Samantha Chan, Jo A. Douglass, Anna Schnell
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2026-02-01
Collection:	Respiratory Research
Sujets:	Bronchiectasis COPD Immunodeficiency Sputum Blood Inflammation
Accès en ligne:	https://doi.org/10.1186/s12931-025-03481-6
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