Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors

Abstract Background Given the role of metabolism in brain health and disease, the investigation of the role of insulin (INS) and insulin-like growth factors (IGFs) as potential therapeutic strategies for neurodegenerative diseases is currently underway. Yet, the signaling pathways associated with IN...

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Autors principals:	Mereena George Ushakumary, Ryan L. Sontag, Camilo Posso, Thomas L. Fillmore, Maisie E. Topping, Heather M. Olson, Philip L. De Jager, David A. Bennett, Zoe Arvanitakis, Vladislav A. Petyuk
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-12-01
Col·lecció:	Cell Communication and Signaling
Matèries:	Proteomics Phosphoproteomics Neural Insulin IGF Rho GTPase
Accés en línia:	https://doi.org/10.1186/s12964-025-02573-6
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