Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

Summary: How neuronal signaling affects brain myelination remains poorly understood. We show dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination. Neuronal Rheb cKO impairs oligodendrocyte differentiation/myelination, with activated neuronal expression of the imprinted gene Dlk1. Ne...

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Detalles Bibliográficos

Principais autores:	Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-07-01
Series:	Cell Reports
Assuntos:	CP: Neuroscience CP: Developmental biology
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124723008124
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