Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines

A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations. Fluorine–amine exchange afforded the corresponding 8-amino-3,4-dihydroisoquinolines, su...

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Bibliografiska uppgifter

Huvudupphov:	Csilla Hargitai, Tamás Nagy, Judit Halász, Gyula Simig, Balázs Volk
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2018-05-01
Serie:	Molecules
Ämnen:	isoquinoline lithiation nucleophilic aromatic substitution reduction alkylation cyclization
Länkar:	http://www.mdpi.com/1420-3049/23/6/1280
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