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B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape

Abstract Background CAR T cell therapy targeting BCMA has shown remarkable efficacy in multiple myeloma (MM), but relapses occur due to T cell exhaustion and the emergence of BCMA-negative subpopulations. Novel targets are needed to overcome antigen escape. Methods B7-H3 (CD276) expression was asses...

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Principais autores: Arne Van der Vreken, Fien Meeus, Chenggong Tu, Lauren van den Broecke, Vincenzo Raimondi, Rosanna Vescovini, Heleen Hanssens, Fenja Watté, Dorien Autaers, Marta Marco Aragon, Janne Billiau, Kim De Veirman, Karin Vanderkerken, Yannick De Vlaeminck, Lorenzo Franceschini, Holly Lee, Paola Neri, Elke De Bruyne, Paola Storti, Nicola Giuliani, Karine Breckpot, Eline Menu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
coleção:Journal of Hematology & Oncology
Assuntos:
B7-H3
CD276
CAR T cells
Multiple myeloma
BCMA
Antigen escape
Acesso em linha:https://doi.org/10.1186/s13045-025-01756-5
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