The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

This work explores the potential of a triple combination of meropenem (MEM), a novel metallo-β-lactamase (MBL) inhibitor (indole-2-carboxylate 58 (InC58)), and a serine-β-lactamase (SBL) inhibitor (avibactam (AVI)) for broad-spectrum activity against carbapenemase-producing bacteria. A diverse panel...

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Egile Nagusiak:	Zhuoren Ling, Alistair James Macdonald Farley, Aditya Lankapalli, Yanfang Zhang, Shonnette Premchand-Branker, Kate Cook, Andrei Baran, Charlotte Gray-Hammerton, Claudia Orbegozo Rubio, Edgars Suna, Jordan Mathias, Jürgen Brem, Kirsty Sands, Maria Nieto-Rosado, Maria Mykolaivna Trush, Nadira Naznin Rakhi, Willames Martins, Yuqing Zhou, Christopher Joseph Schofield, Timothy Walsh
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2024-07-01
Saila:	Engineering
Gaiak:	Carbapenemase Metallo/serine-β-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2095809924002297
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