Physiologically Based Biopharmaceutics Modeling of Food Effect for Basmisanil: A Retrospective Case Study of the Utility for Formulation Bridging

Basmisanil, is a lipophilic drug substance, exhibiting poor solubility and good permeability (BCS class 2). A validated physiologically based biopharmaceutics model (PBBM) has been previously described for tablets dosed in the fed state. The PBBM captured the less than proportional increases in expo...

Descrición completa

Detalles Bibliográficos

Principais autores:	Tejashree Belubbi, Davide Bassani, Cordula Stillhart, Neil Parrott
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2023-01-01
Series:	Pharmaceutics
Assuntos:	food effect oral absorption PBBM immediate-release formulation poorly water-soluble compound GastroPlus™
Acceso en liña:	https://www.mdpi.com/1999-4923/15/1/191
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!