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New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation in different metabolic pathways in the human...

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Principais autores: Doretta Cuffaro, Riccardo Di Leo, Lidia Ciccone, Alessio Nocentini, Claudiu T. Supuran, Elisa Nuti, Armando Rossello
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2023-12-01
coleção:Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:
Carbonic anhydrase activators
isoxazolines
neurodegenerative diseases
amino alcohols
metalloenzymes
Acesso em linha:https://www.tandfonline.com/doi/10.1080/14756366.2022.2164574
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