A novel aptamer-based dNTP assay reveals that intact HIV virions are highly stable and do not contain enough dNTPs to support DNA synthesis
ABSTRACT HIV virions contain high concentrations of IP6 (inositol hexakisphosphate), which stabilize capsids by binding to pores that allow dNTPs to import into capsids during infection. The concentration of dNTPs in virions, however, is not known. The low cellular concentrations (~5 µM each) predic...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2025-08-01
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| Serie: | Journal of Virology |
| Soggetti: | |
| Accesso online: | https://journals.asm.org/doi/10.1128/jvi.00564-25 |
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