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Intrahepatic cholestasis of pregnancy associated with azathioprine: first quantitative disproportionality analysis using the FDA adverse event reporting system

IntroductionAzathioprine (AZA) is an immunosuppressant approved for renal transplant rejection and rheumatoid arthritis. Recent FDA alerts have raised concerns about its link to intrahepatic cholestasis of pregnancy (ICP), a condition with serious maternal and fetal risks. This study used disproport...

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Principais autores: Yonghoon Kwon, Nai Lee, Yun Kim
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2025-12-01
סדרה:Journal of Pharmacy & Pharmaceutical Sciences
נושאים:
azathioprine
intrahepatic cholestasis of pregnancy
pregnancy safety
pharmacovigilance
signals of disproportionate reporting
גישה מקוונת:https://www.frontierspartnerships.org/articles/10.3389/jpps.2025.15527/full
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