Microvascular pathology in the spinal cord of severe spinal muscular atrophy patients

Abstract Severe spinal muscular atrophy (SMA) is a life-limiting neurodegenerative disease of infancy and early childhood, caused by reduced expression of the ubiquitous survival motor neuron protein (SMN). While current therapies aim to increase SMN levels and preserve motor neurons, significant de...

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Autors principals:	Hazel Allardyce, Heather Lanz, Benjamin D. Lawrence, Thomas O. Crawford, Charlotte J. Sumner, Simon H. Parson
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	von Willebrand Factor Endothelial cell BSCB Astrocytes Pericytes Microglia
Accés en línia:	https://doi.org/10.1186/s40478-026-02232-y
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