The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘en...
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| Principais autores: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2021-09-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-021-25862-3 |
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