A Cell‐Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer‐Specific Synthetic Lethality

Abstract Despite advances in precision oncology, cancer remains a global public health issue. In this report, proof‐of‐principle evidence is presented that a cell‐penetrable peptide (ACP52C) dissociates transcription factor CP2c complexes and induces apoptosis in most CP2c oncogene‐addicted cancer c...

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Detalhes bibliográficos

Principais autores:	Seung Han Son, Min Young Kim, Sungwoo Choi, Ji Sook Kim, Yong Sang Lee, Sangwon Lee, Yeon Ju Lee, Jin Youn Lee, Seol Eui Lee, Young Su Lim, Dae Hyun Ha, Eonju Oh, Young‐Bin Won, Chang‐Jun Ji, Mi Ae Park, Boram Kim, Kyu Tae Byun, Min Sung Chung, Jaemin Jeong, Dongho Choi, Eun Jung Baek, Eung‐Ho Cho, Sang‐Bum Kim, A. Reum Je, Hee‐Seok Kweon, Hyun Sook Park, Dongsun Park, June Sung Bae, Se Jin Jang, Chae‐Ok Yun, Ji Hyung Chae, Jin‐Won Lee, Su‐Jae Lee, Chan Gil Kim, Ho Chul Kang, Vladimir N. Uversky, Chul Geun Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2023-11-01
coleção:	Advanced Science
Assuntos:	a cell‐penetrant peptide CP2c complex disruption pan‐anticancer drug synthetic lethality transcription factor CP2c
Acesso em linha:	https://doi.org/10.1002/advs.202305096
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