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Lack of strong innate immune reactivity renders macrophages alone unable to control productive Varicella-Zoster Virus infection in an isogenic human iPSC-derived neuronal co-culture model

With Varicella-Zoster Virus (VZV) being an exclusive human pathogen, human induced pluripotent stem cell (hiPSC)-derived neural cell culture models are an emerging tool to investigate VZV neuro-immune interactions. Using a compartmentalized hiPSC-derived neuronal model allowing axonal VZV infection,...

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Principais autores: Elise Van Breedam, Tamariche Buyle-Huybrecht, Jonas Govaerts, Pieter Meysman, Andrea Bours, Marlies Boeren, Julia Di Stefano, Thalissa Caers, Hans De Reu, Laura Dirkx, Jolien Schippers, Esther Bartholomeus, Marielle Lebrun, Catherine Sadzot-Delvaux, Paulina Rybakowska, Marta E. Alarcón-Riquelme, Concepción Marañón, Kris Laukens, Peter Delputte, Benson Ogunjimi, Peter Ponsaerts
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-05-01
coleção:Frontiers in Immunology
Assuntos:
varicella zoster virus
iPSC
neurons
macrophages
neuronal models
axonal infection
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1177245/full
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