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FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA

Abstract Background Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment. Dysregulation of N6-methyladenosine (m6A) modification has been impli...

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Principais autores: Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan, Jie Zan
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2023-09-01
Series:Journal of Translational Medicine
Assuntos:
Parkinson’s disease
N6-methyladenosine modification
FTO
siRNA
Exosomes
Acceso en liña:https://doi.org/10.1186/s12967-023-04461-4
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