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Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence

Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In contrast, pre-pubertal (type I) GCTs are limited t...

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Principais autores: Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2023-05-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-38378-9
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