Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms

Abstract Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is understood of the mechanistic differences among tumor-driving IDH1 mutants. We pre...

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Principais autores:	Matthew Mealka, Nicole A. Sierra, Diego Avellaneda Matteo, Elene Albekioni, Rachel Khoury, Timothy Mai, Brittany M. Conley, Nalani J. Coleman, Kaitlyn A. Sabo, Elizabeth A. Komives, Andrey A. Bobkov, Andrew L. Cooksy, Steve Silletti, Jamie M. Schiffer, Tom Huxford, Christal D. Sohl
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-05-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-48277-2
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