GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment

Summary: Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers NT5E/CD73 ecto-enzyme expression, augmenting the conversio...

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Ngā kaituhi matua:	Bircan Coban, Zi Wang, Chen-yi Liao, Klara Beslmüller, Mieke A.M. Timmermans, John W.M. Martens, Jasmijn H.M. Hundscheid, Bram Slutter, Annelien J.M. Zweemer, Elsa Neubert, Erik H.J. Danen
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2024-05-01
Rangatū:	iScience
Ngā marau:	Molecular biology Immunology Cell biology Cancer
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S258900422400960X
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!