Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation

Abstract Background Elevated FSH often occurs in women of advanced maternal age (AMA, age ≥ 35) and in infertility patients undergoing controlled ovarian stimulation (COS). There is controversy on whether high endogenous FSH contributes to infertility and whether high exogenous FSH adversely impacts...

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Hlavní autoři:	Lori R. Bernstein, Amelia C. L. Mackenzie, Charles L. Chaffin, Se-Jin Lee, Duane C. Kraemer, Istvan Merchenthaler
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-05-01
Edice:	Reproductive Biology and Endocrinology
Témata:	eCG FSH Ootoxicity Oocyte maturation ActRIIB:Fc SAMP8 mice
On-line přístup:	https://doi.org/10.1186/s12958-024-01224-8
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