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Alpha-1 antitrypsin Pi∗Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease

Background & Aims: Alpha-1 antitrypsin (AAT) deficiency causes/predisposes individuals to advanced chronic liver disease (ACLD). However, the role of the SERPINA1 Pi∗Z allele in patients who have already progressed to ACLD is unclear. Thus, we aimed to evaluate the impact of the Pi∗Z allele on t...

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Principais autores: Lorenz Balcar, Bernhard Scheiner, Markus Urheu, Patrick Weinberger, Rafael Paternostro, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, David Bauer, Georg Semmler, Claudia Willheim, Matthias Pinter, Peter Ferenci, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-11-01
coleção:JHEP Reports
Assuntos:
AATD
cirrhosis
prognostication
genetic risk
rare disease
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589555922001343
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