A novel PML::RARA fusion in acute promyelocytic leukemia: a case report and literature review

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by the t(15;17)(q24;q21)-derived PML::RARA fusion. However, a small subset of patients harbor cryptic or atypical RARA rearrangements that escape detection by routine real-time quantitative RT-PCR (qRT-PCR). W...

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Auteurs principaux:	Jia-Ping Chen, Jun-Jie Hou, Xiao-Yong Chen, Yi-Xuan Cao, Peng Ke, Ji-Hao Zhou, Li-Na Hu
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-04-01
Collection:	Frontiers in Oncology
Sujets:	APL FLT3-ITD PML::RARA fusion transcripts RARA rearrangements real-time quantitative PCR assays RNA sequencing
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1784103/full
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