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Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections

Abstract Objectives We aimed to analyze the genomic variations associated with high azole resistance in the C. albicans isolates of intensive care unit (ICU) patients with Candida bloodstream infections (BSIs) and those from oropharyngeal colonization in HIV patients. Methods The genomic DNA of azol...

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Principais autores: Ming-Horng Tsai, Chih-Hung Hsieh, I.-An Tsai, Ching-Min Chang, Ting-Wen Chen, Jen-Fu Hsu, Shih-Ming Chu, Hsuan-Rong Huang, Shao-Hung Wang, Jang-Jih Lu
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-02-01
Series:Journal of Biomedical Science
Assuntos:
Candida albicans
Antifungal susceptibility testing
Azoles resistance
Candida bloodstream infection
ERG11 efflux genes
Acceso en liña:https://doi.org/10.1186/s12929-026-01231-4
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