SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2

Dysregulation of protein posttranslational modification (PTM) can lead to a variety of pathological processes, such as abnormal sperm development, malignant tumorigenesis, depression, and aging process. SIRT7 is a NAD+-dependent protein deacetylase. Besides known deacetylation, SIRT7 may also have t...

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Hlavní autoři:	Ai Qing Yu, Jie Wang, Shi Tao Jiang, Li Qun Yuan, Hai Yan Ma, Yi Min Hu, Xing Min Han, Li Ming Tan, Zhi Xiao Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-09-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	Sirt7 PHF5A crotonylation cellular aging alternative splicing
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2021.710479/full
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