Systematic identification of placental epigenetic signatures for the noninvasive prenatal detection of Edwards syndrome.

BACKGROUND: Noninvasive prenatal diagnosis of fetal aneuploidy by maternal plasma analysis is challenging owing to the low fractional and absolute concentrations of fetal DNA in maternal plasma. Previously, we demonstrated for the first time that fetal DNA in maternal plasma could be specifically ta...

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Autori principali:	Dana W Y Tsui, Y M Doris Lam, Wing S Lee, Tak Y Leung, Tze K Lau, Elizabeth T Lau, Mary H Y Tang, Ranjit Akolekar, Kypros H Nicolaides, Rossa W K Chiu, Y M Dennis Lo, Stephen S C Chim
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2010-01-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC2994810?pdf=render
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