Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep.

A major limitation to adeno-associated virus (AAV) gene therapy is the generation of host immune responses to viral vector antigens and the transgene product. The ability to induce immune tolerance to foreign protein has the potential to overcome this host immunity. Acquisition and maintenance of to...

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Hlavní autoři:	Marcus G Davey, John S Riley, Abigail Andrews, Alec Tyminski, Maria Limberis, Jennifer E Pogoriler, Emily Partridge, Aliza Olive, Holly L Hedrick, Alan W Flake, William H Peranteau
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2017-01-01
Edice:	PLoS ONE
On-line přístup:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171132&type=printable
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