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An ADR pharmaceutical care for severe gastrointestinal bleeding of rivaroxaban in a patient with nonvalvular atrial fibrillation based on TDM and genetic testing: a case report

Abstract Background Due to its predictable pharmacodynamics and pharmacokinetics, stable blood concentration, and relatively short half-life, rivaroxaban is widely used in the prevention and treatment of thrombosis. It nevertheless exhibits a certain level of inter-individual variability, and its sa...

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Principais autores: Youqi Huang, Hongjin Gao, Mingyu Chen, Yuze Lin, Huiting Liu, Min Chen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-10-01
Serier:BMC Medical Genomics
Fag:
Rivaroxaban
Gastrointestinal bleeding
Adverse drug reactions
ABCB1 gene polymorphism
Therapeutic drug monitoring
Drug-drug interaction
Online adgang:https://doi.org/10.1186/s12920-025-02222-4
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