miR-126和miR-199对乳腺癌细胞周期进程的影响
目的探讨miR-126和miR-199在乳腺癌细胞中的表达对肿瘤细胞周期的影响。方法以qRT-PCR检测分析在乳腺癌细胞中miR-126和miR-199的表达情况;以miRNA mimics转染乳腺癌细胞株MDA-MB-231,检测miR-126和miR-199在表达增高的情况下对乳腺癌细胞周期的影响。结果miR-126和miR-199在乳腺癌细胞MDA-MB-231中的表达较MCF-7细胞株明显更低;转染miRNA mimics 48h后,乳腺癌细胞株MDA-MB-231中的miR-126和miR-199的表达显著上调,可促进细胞凋亡,阻滞乳腺癌细胞周期进程。结论提高miR-126和miR-...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Chinês |
| Baskı/Yayın Bilgisi: |
Editorial Office of Chinese Journal of Laboratory Diagnosis
2017-01-01
|
| Seri Bilgileri: | Zhongguo shiyan zhenduanxue |
| Konular: | |
| Online Erişim: | http://ZSZD.publish.founderss.cn/thesisDetails?columnId=88470033&Fpath=home&index=0 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|