Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model

Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)‐related acid‐sensitive K+ channel (TASK‐1; hK2P3.1) two‐pore–domain potassium channel was recently shown to regulate the atrial action potential duration. In the human heart, TASK‐1 channels are specifically expressed i...

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Principais autores:	Felix Wiedmann, Christoph Beyersdorf, Xiaobo Zhou, Antonius Büscher, Manuel Kraft, Jendrik Nietfeld, Teo Puig Walz, Laura A. Unger, Axel Loewe, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Dierk Thomas, Martin Borggrefe, Gunnar Seemann, Hugo A. Katus, Constanze Schmidt
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Wiley 2020-05-01
סדרה:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
נושאים:	A293 antiarrhythmic pharmacotherapy atrial fibrillation cardioversion K2P3.1 TASK‐1
גישה מקוונת:	https://www.ahajournals.org/doi/10.1161/JAHA.119.015751
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